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GLP-1 stimulates type 3 iodothyronine deiodinase (D3) expression through the GLP-1 receptor, and the regulation of intracellular (T3) concentration by D3 may be involved in the stimulation of insulin secretion by GLP-1 (75)
Polymeric nanoparticles, especially those derived from PLGA (poly(lactic-co-glycolic acid)), have been used to prepare long-acting formulations of GLP-1 that can extend the release period to weeks with a single dose, reducing injection frequency and improving patient adherence [33]
It slows stomach emptying which leads to a slower flow of sugar from the bloodstream to your stomach, ultimately reducing the risk of a blood sugar spike
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